منابع مشابه
Microneedles for drug and vaccine delivery.
Microneedles were first conceptualized for drug delivery many decades ago, but only became the subject of significant research starting in the mid-1990's when microfabrication technology enabled their manufacture as (i) solid microneedles for skin pretreatment to increase skin permeability, (ii) microneedles coated with drug that dissolves off in the skin, (iii) polymer microneedles that encaps...
متن کاملMicroneedles-mediated drug and vaccine delivery
Several decades past, the concept of microneedles was laid down but turned out to be the area under research in the mid 1990’s due to their production via microfabrication technology. A plethora of troubles has been associated with injection by needle-and-syringe-based delivery of drug and vaccine comprising patient compliance and acceptability, pain of needles, needlestick injuries, requiremen...
متن کاملMicroneedles for Ocular Drug Delivery
Statement of Purpose: Targeted drug delivery into the eye is a challenging task because of a variety of barriers that prevent safe and effective delivery. Topical application to the eye is hindered by low residence time resulting in poor diffusion of drug into intraocular tissues. Intravitreal injection can deliver drugs to the retina effectively but is invasive and carries risk of infection. I...
متن کاملMicroneedles for transdermal drug delivery.
The success of transdermal drug delivery has been severely limited by the inability of most drugs to enter the skin at therapeutically useful rates. Recently, the use of micron-scale needles in increasing skin permeability has been proposed and shown to dramatically increase transdermal delivery, especially for macromolecules. Using the tools of the microelectronics industry, microneedles have ...
متن کاملA review of the microneedles for transdermal drug delivery
Microneedles consist of micron-sized projections similar to needles. They are capable of piercing through the stratum corneum and increase the permeation of active ingredients. Besides active pharmaceutical ingredients, microneedles can also deliver cosmetic agents, biotherapeutics like insulin and vaccines and also are used in diagnostic purposes. This article examines the types of microneedle...
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ژورنال
عنوان ژورنال: Advanced Drug Delivery Reviews
سال: 2012
ISSN: 0169-409X
DOI: 10.1016/j.addr.2012.04.005